Surgical Management of Genital Ambiguity

January 12, 2008 on 12:39 pm | In Gynecology | Comments Off

Mark R. Feneley and John P. Gearhart
Management of the infant with ambiguous genitalia demands great care and skill. Gender assignment requires careful clinical evaluation and full understanding of its implications for future sexual and psychological development as well as fertility. The surgeon must be sensitive to concerns of the parents and the future development of […]

Gender Assignment

January 10, 2008 on 11:53 am | In Gynecology | Comments Off

Claude J. Migeon and Gary D. Berkovitz
Gender assignment is a complex issue, yet decisions need to be made as quickly as possible after the birth of an intersex child concerning male or female sex of rearing. Gender assignment is best guided by an experienced medical team including a pediatric endocrinologist/urologist/gynecologist and medical psychologist so that […]

Workup of Prepubertal Children With Ambiguous Genitalia

January 9, 2008 on 9:53 pm | In Gynecology | Comments Off

Claude J. Migeon and Gary D. Berkovitz
The workup of ambiguous external genitalia described in the previous section was devised for newborn infants. It is extremely important to establish early in life the etiology of the ambiguous genitalia and the preferred sex of rearing. Experience has shown that it is hazardous to make a change in […]

Workup of Newborns With Ambiguous External Genitalia

January 9, 2008 on 9:48 pm | In Gynecology | Comments Off

Claude J. Migeon and Gary D. Berkovitz
As already stated, it is an emergency to determine the etiology of the ambiguous genitalia because it will help in the decision making as far as the sex of rearing is concerned. It also can be a medical emergency as, in some cases, the mutation responsible for the abnormal […]

Physiology of Sexual Differentiation

December 13, 2007 on 6:10 am | In Gynecology | Comments Off

Claude J. Migeon and Gary D. Berkovitz
The first step in sex differentiation is the determination of genetic sex (XX or XY) at the time of conception. Nonetheless, the external genitalia of the male and female fetus appear to be identical at 6 weeks of gestation. This neutral genitalia includes the genital tubercle, the labioscrotal folds, […]

Physical Events of Puberty

December 3, 2007 on 10:26 am | In Gynecology | Comments Off

Sander S. Shapiro and Joel S. Krasnow
In utero, the fetus is exposed to high estrogen levels. Acute withdrawal of estrogen at birth can result in endometrial shedding, which manifests clinically as vaginal bleeding. In infant girls between 1 and 6 months of age, the uterus decreases in size, achieving an average length of 32 mm. […]

Initiation of Gonadarche

November 28, 2007 on 8:33 am | In Gynecology | Comments Off

Sander S. Shapiro and Joel S. Krasnow
The alterations in physical characteristics that occur around puberty are largely dependent on sex steroid production by the gonads. The process of ovarian follicular growth and atresia is a continuous process initiated in utero. Both ultrasound and autopsy studies have documented cystic changes in the ovaries from birth to […]

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